20 PagesPosted: 6 Dec 2024
See all articles by Zheng-Li Xu
Zheng-Li Xu
affiliation not provided to SSRN
Yu-Ping Zhang
affiliation not provided to SSRN
Bao-dong Ye
Zhejiang University of Traditional Chinese Medicine
Xin Zhao
affiliation not provided to SSRN
Ming Zhou
affiliation not provided to SSRN
Peihua Lu
Hebei Yanda Lu Daopei Hospital - Department of Hematology
Zi-Min Sun
affiliation not provided to SSRN
Xin Li
Central South University
Er-Lie Jiang
affiliation not provided to SSRN
Dai-Hong Liu
Government of the People's Republic of China - Chinese PLA General Hospital
Yajing Xu
affiliation not provided to SSRN
Fang Zhou
affiliation not provided to SSRN
Li Liu
affiliation not provided to SSRN
Xi Zhang
Government of the People's Republic of China - Medical Center of Hematology; Government of the People's Republic of China - Department of Hematology; Government of the People's Republic of China - State Key Laboratory of Trauma, Burns and Combined Injury
Xian-Ming Song
Shanghai Jiao Tong University (SJTU) - Shanghai General Hospital
Jian-ping Zhang
Hebei Yanda Lu Daopei Hospital
Hai Yi
affiliation not provided to SSRN
Xue-Jun Zhang
affiliation not provided to SSRN
Xuehong Ran
Shandong Second Medical University
Guo-Hong Su
Cangzhou Central Hospital
Yan-Ming Zhang
affiliation not provided to SSRN
Jieping Chen
Government of the People's Republic of China - Center for Hematology
Jin-Xiong Huang
affiliation not provided to SSRN
Chun Wang
affiliation not provided to SSRN
Hai-Ping Yang
affiliation not provided to SSRN
Pengcheng He
Xi'an Jiaotong University (XJTU) - Department of Hematology
Nan Su
affiliation not provided to SSRN
Ziwen Guo
Zhongshan City People's Hospital
Wu Tong
Beijing Gobroad Boren Hospital
Guanchen Bai
Qingdao University - Department of Hepatology
Sheng-Jin Fan
affiliation not provided to SSRN
Xiao-Jun Huang
Peking University - Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation; Southern Medical University - Nanfang Hospital; Peking University - Peking-Tsinghua Center for Life Sciences; Chinese Academy of Medical Sciences - Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies; Peking University - Institute of Hematology
Shunqing Wang
South China University of Technology - Department of Hematology
Lan-Ping Xu
Peking University - Institute of Hematology
Abstract
Our study includes 278 patients aged between 40 and 50 years from 29 centers who received allogeneic hematopoietic stem cell transplantation (alloHSCT) from MSDs (n=106) and HIDs (n=172) over the last decade. Univariate analysis revealed that HID recipients was associated with more serious disease severity, a delayed alloHSCT after diagnosis, a higher pretransplant transfusion burden and poor performance status pre-transplant than MSD recipients in clinical settings. After these pretransplant clinical factors were well balanced following propensity score-matching (PSM), 80 matched pairs were selected for further analysis. Following PSM, the cumulative incidences of neutrophil were comparable between two matched groups (P = 0.14), while the 100-day engraftment rates of platelet were significant lower in HID-HCT (P < 0.001); The HID cohort showed higher cumulative incidence of grade II-IV acute graft-versus-host disease (GVHD) compared with MSD group (P = 0.04). In contrast, the incidence of severe (grade III-IV) acute GVHD and chronic GVHD were not statistically significant (severe acute GVHD P = 0.10; chronic GVHD P = 0.28). Our study showed comparable overall survival (OS) (P = 0.14); failure free survival (FFS) (P = 0.23); GVHD-free/relapse-free survival (GRFS) (P = 0.18) between matched HID and MSD recipients. In conclusion, our data indicates that alloHSCT from an HID should be considered for SAA patients between 40-50 years old who do not have an MSD.
Note:
Funding Declaration: This work was supported by the Peking University People’s Hospital Research andDevelopment Funds (RS2023-02).
Conflicts of Interest: None.
Ethical Approval: The study was approvedby each institutional review board at the 29 participating institutions. Written informed consentwas obtained from all patients/legal guardians, in accordance with the Declarationof Helsinki.
Keywords: Aplastic anemia, hematopoietic stem cell transplantation, haploidentical donor, matched sibling donor
Suggested Citation:Suggested Citation
Xu, Zheng-Li and Zhang, Yu-Ping and Ye, Bao-dong and Zhao, Xin and Zhou, Ming and Lu, Peihua and Sun, Zi-Min and Li, Xin and Jiang, Er-Lie and Liu, Dai-Hong and Xu, Yajing and Zhou, Fang and Liu, Li and Zhang, Xi and Song, Xian-Ming and Zhang, Jian-ping and Yi, Hai and Zhang, Xue-Jun and Ran, Xuehong and Su, Guo-Hong and Zhang, Yan-Ming and Chen, Jieping and Huang, Jin-Xiong and Wang, Chun and Yang, Hai-Ping and He, Pengcheng and Su, Nan and Guo, Ziwen and Tong, Wu and Bai, Guanchen and Fan, Sheng-Jin and Huang, Xiao-Jun and Wang, Shunqing and Xu, Lan-Ping, Comparable Survival Outcomes in Hla-Matched and Haploidentical Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia Patients Aged 40-50: A Cbmtr Registry-Based Propensity Score Matching Analysis Over the Last Decade. Available at SSRN: https://ssrn.com/abstract=5039836 or http://dx.doi.org/10.2139/ssrn.5039836
Zheng-Li Xu
affiliation not provided to SSRN ( email )
No Address Available
Yu-Ping Zhang
affiliation not provided to SSRN ( email )
No Address Available
Bao-dong Ye
Zhejiang University of Traditional Chinese Medicine ( email )
Wenzhou
China
Xin Zhao
affiliation not provided to SSRN ( email )
No Address Available
Ming Zhou
affiliation not provided to SSRN ( email )
No Address Available
Peihua Lu
Hebei Yanda Lu Daopei Hospital - Department of Hematology ( email )
Langfang
China
Zi-Min Sun
affiliation not provided to SSRN ( email )
No Address Available
Xin Li
Central South University ( email )
Er-Lie Jiang
affiliation not provided to SSRN ( email )
No Address Available
Dai-Hong Liu
Government of the People's Republic of China - Chinese PLA General Hospital ( email )
Beijing, 100853
China
Yajing Xu
affiliation not provided to SSRN ( email )
No Address Available
Fang Zhou
affiliation not provided to SSRN ( email )
No Address Available
Li Liu
affiliation not provided to SSRN ( email )
No Address Available
Xi Zhang
Government of the People's Republic of China - Medical Center of Hematology ( email )
Chongqing
China
Government of the People's Republic of China - Department of Hematology ( email )
Chongqing
China
Government of the People's Republic of China - State Key Laboratory of Trauma, Burns and Combined Injury ( email )
China
Xian-Ming Song
Shanghai Jiao Tong University (SJTU) - Shanghai General Hospital ( email )
China
Jian-ping Zhang
Hebei Yanda Lu Daopei Hospital ( email )
Langfang
China
Hai Yi
affiliation not provided to SSRN ( email )
No Address Available
Xue-Jun Zhang
affiliation not provided to SSRN ( email )
No Address Available
Xuehong Ran
Shandong Second Medical University ( email )
Guo-Hong Su
Cangzhou Central Hospital ( email )
Cangzhou
China
Yan-Ming Zhang
affiliation not provided to SSRN ( email )
No Address Available
Jieping Chen
Government of the People's Republic of China - Center for Hematology ( email )
Jin-Xiong Huang
affiliation not provided to SSRN ( email )
No Address Available
Chun Wang
affiliation not provided to SSRN ( email )
No Address Available
Hai-Ping Yang
affiliation not provided to SSRN ( email )
No Address Available
Pengcheng He
Xi'an Jiaotong University (XJTU) - Department of Hematology ( email )
Nan Su
affiliation not provided to SSRN ( email )
No Address Available
Ziwen Guo
Zhongshan City People's Hospital ( email )
Wu Tong
Beijing Gobroad Boren Hospital ( email )
Beijing
China
Guanchen Bai
Qingdao University - Department of Hepatology ( email )
Sheng-Jin Fan
affiliation not provided to SSRN ( email )
No Address Available
Xiao-Jun Huang
Peking University - Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation ( email )
No. 11 Xizhimen South Street
Beijing, 100044
China
Southern Medical University - Nanfang Hospital
Guangzhou
China
Peking University - Peking-Tsinghua Center for Life Sciences
Beijing
China
Chinese Academy of Medical Sciences - Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies
Beijing, 2019RU029
China
Peking University - Institute of Hematology ( email )
Beijing
China
Shunqing Wang
South China University of Technology - Department of Hematology ( email )
Lan-Ping Xu (Contact Author)
Peking University - Institute of Hematology ( email )
Beijing
China
